Recent paper showing that Two-Pore Channels are integral components of the NAADP-sensitive Ca2+ release mechanism in the endolysosomal system.Embo J. 34, 1743-58 (2015).
A recent review of the mechanisms underlying lysosomal storage diseases.Nature 510, 68-75 (2014).
A paper outlining the use of in silico drug discovery software to generate a selective inhibitor of NAADP/Two-Pore Channel-mediated calcium signalling.Nat. Chem. Biol. 5, 220-226 (2009).
A review outlining the concept of the endolysosomal system as a regulated calcium store.Biochem. J. 439, 349-374 (2011).
A review highlighting the pathophysiology of the NAADP-TPC-lysosomal calcium signalling mechanism in various cells and organs.Cell Calcium 58, 27-47 (2014).
Defines the rare lysosomal storage disease Niemann-Pick type C as the first human disease resulting from endolysosomal calcium dysfunction, and demonstrates that correction of cellular calcium homeostasis can improve disease symptoms.Nature Medicine 14, 1247-1255 (2008).
Journal of Neurology. 264 (2017).
Amino Acids. 2015 May;47(5):917-24. doi: 10.1007/s00726-015-1920-6. Epub 2015 Jan 25. PMID: 25618754.