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EXPRESSION OF CA2+-PERMEABLE TWO-PORE CHANNELS (TPC) RESCUES NAADP-SIGNALLING IN TPC-DEFICIENT CELLS.

RUAS, M., DAVIS, L. C., CHEN, C. C., MORGAN, A. J., CHUANG, K. T., WALSETH, T. F., GRIMM, C., GARNHAM, C., POWELL, T., PLATT, F. M., BIEL, M., WAHL-SCHOTT, C., PARRINGTON, J., AND GALIONE, A.

Recent paper showing that Two-Pore Channels are integral components of the NAADP-sensitive Ca2+ release mechanism in the endolysosomal system.Embo J. 34, 1743-58 (2015).

Pub Med

SPHINGOLIPID LYSOSOMAL STORAGE DISORDERS.

PLATT, F. M.

A recent review of the mechanisms underlying lysosomal storage diseases.Nature 510, 68-75 (2014).

Pub Med

IDENTIFICATION OF A CHEMICAL PROBE FOR NAADP BY VIRTUAL SCREENING.

NAYLOR, E., ARREDOUANI, A., VASUDEVAN, S. R., LEWIS, A. M., PARKESH, R., MIZOTE, A., ROSEN, D., THOMAS, J. M., IZUMI, M., GANESAN, A., GALIONE, A., AND CHURCHILL, G. C.

A paper outlining the use of in silico drug discovery software to generate a selective inhibitor of NAADP/Two-Pore Channel-mediated calcium signalling.Nat. Chem. Biol. 5, 220-226 (2009).

Pub Med

MOLECULAR MECHANISMS OF ENDOLYSOSOMAL CA2+ SIGNALLING IN HEALTH AND DISEASE.

MORGAN, A. J., PLATT, F. M., LLOYD-EVANS, E. & GALIONE, A.

A review outlining the concept of the endolysosomal system as a regulated calcium store.Biochem. J. 439, 349-374 (2011).

Pub Med

A PRIMER OF NAADP-MEDIATED CA2+-SIGNALLING: FROM SEA URCHIN EGGS TO MAMMALIAN CELLS

GALIONE, A.

A review highlighting the pathophysiology of the NAADP-TPC-lysosomal calcium signalling mechanism in various cells and organs.Cell Calcium 58, 27-47 (2014).

Pub Med

NIEMANN-PICK DISEASE TYPE C1 IS A SPHINGOSINE STORAGE DISEASE THAT CAUSES DEREGULATION OF LYSOSOMAL CALCIUM

LLOYD-EVANS, E., MORGAN, A. J., HE, X., SMITH, D. A., ELLIOT-SMITH, E., SILLENCE, D. J., CHURCHILL, G. C., SCHUCHMAN, E. H., GALIONE, A., AND PLATT, F. M.

Defines the rare lysosomal storage disease Niemann-Pick type C as the first human disease resulting from endolysosomal calcium dysfunction, and demonstrates that correction of cellular calcium homeostasis can improve disease symptoms.Nature Medicine 14, 1247-1255 (2008).

Pub Med

GAIT ATAXIA IN HUMANS: VESTIBULAR AND CEREBELLAR CONTROL OF DYNAMIC STABILITY

SCHNIEPP, R. MOHWALD, K. WUEHR, M.

Journal of Neurology. 264 (2017).

Pub Med

A (14)C-LEUCINE ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION (ADME) STUDY IN ADULT SPRAGUE-DAWLEY RAT REVEALS Β-HYDROXY-Β-METHYLBUTYRATE AS A METABOLITE.

LEE AJ, BENO DW, ZHANG X, SHAPIRO R, MASON M, MASON-BRIGHT T, SURBER B, EDENS NK.

Amino Acids. 2015 May;47(5):917-24. doi: 10.1007/s00726-015-1920-6. Epub 2015 Jan 25. PMID: 25618754.

Pub Med
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